The Binding of Isaac has sold over 2 million copies, according to creator Edmund McMillen. McMillan is currently working on the remake titled The Binding of Isaac: Rebirth.

The remake will use a new engine and not use Flash, allowing for more to happen on the screen at once. Along with an huge expansion to content, it will allow for two-player co-op.

The Binding of Isaac: Rebirth is currently set for release on PC, Vita, and PS3, with 3DS and Xbox 360 releases possible.

Source: Destructoid.com